Curcumin anti inflammatory The clinical efficacy of curcumin in OA has been evaluated in many clinical trials [ 2 – 15 ]. A growing body of evidence indicates that oxidative stress, free radicals, beta amyloid, cerebral deregulation caused by bio-metal toxicity and abnormal inflammatory reactions contribute to the key event in Alzheimer's disease pathology. These results suggest that 4 weeks of curcumin supplementation resulted in significantly lower concentrations of proinflammatory cytokines in adults who recovered from COVID-19 infection and were subsequently vaccinated. This study aimed to investigate anti-gout and anti-inflammatory properties of curcumin nanoparticles (CNPs). Epub Curcumin intake confers anti-inflammatory activity and may be a promising prophylactic nutraceutical strategy for COVID-19. Curcumin is a hydrophobic polyphenol, the active component of the rhizome of the plant Curcuma longa (CL). The impact of regular consumption of curcumin have already been claimed in relation to long-term, metabolic-rooted disorders, such as overweight/obesity [13], type 2 diabetes mellitus [14], and even cognitive and psychological abnormalities, such as Alzheimer’s disease and dementia [15], [16]. The effects of curcumin on selected immune cells involved in the course of rheumatoid arthritis. 11 Hemoxygenase-1 gene expression can also be induced by curcumin through The anti-inflammatory impact of berberine and curcumin may decrease oxidative stress, liver inflammation, and lipid metabolism (Feng et al. 1. The main purposes of this study are to explore the therapeutic effects of curcumin on collagen-induced arthritis (CIA Chemokines belong to the family of cytokines with chemoattractant properties that regulate chemotaxis and leukocyte migration, as well as the induction of angiogenesis and maintenance of hemostasis. Its simple molecular structure, high efficacy, variable therapeutic effects and multidimensional use make it ideal for various treatment regimens. We have shown that short-term cell treatment with low concentrations of curcumin has a positive effect on normal young cells by decreasing the level of secreted pro-inflammatory cytokines. Many cellular targets of curcumin have been identified, but how such a wide range of targets can be affected by a single compound is unclear. 2010;10(7):815–818 Curcumin, due to its anti-inflammatory properties, can inhibit NF-κB activity and decrease the level of TNFα, which is the most effective activator of the NF-κB pathway [81,107]. doi: 10. How oxidative stress activates inflammatory pathways leading to the progression of chronic diseases is the focus of this review. Curcumin can maintain Curcumin as an anti-inflammatory and antioxidant compound possesses anti-rheumatic and anti-arthritic properties [88,89]. This study demonstrated that curcumin had anti-inflammatory activity in LTA-stimulated microglial cells may through inhibiting NF-κB and p38 MAPK activation, and may induce the expression of Nrf2 and HO-1 (Figure 6). Moreover, in line with the theme of this series, the role of inflammation and stress in these diseases and possible anti-inflammatory effects of curcumin, as well as its interaction with signal transduction proteins as a common denominator in its varied mechanisms of action, are also discussed. Due to their low solubility in water, Identification Generic Name Curcumin DrugBank Accession Number DB11672 Background. Turmeric extract or active component curcumin may have anti-inflammatory effects in people with chronic inflammatory diseases. However, studies have indicated that turmeric oil, present in turmeric, can enhance the bioavailability of curcumin. Several human disorders, including fibrosis, lupus nephritis, acne, cancer, diabetes, and irritable bowel syndrome, have been tested in clinics. Ingesting curcumin by itself does not lead to the associated health benefits due to its poor bioavailability, which appears to be primarily due to poor absorption, rapid metabolism, Oxidative damage and inflammation have been pointed out in preclinical studies as the root cause of cancer and other chronic diseases such as diabetes, hypertension, Alzheimer’s disease, etc. While it seems to have countless therapeutic Curcumin is a hydrophobic polyphenol, the active component of the rhizome of the plant Curcuma longa (CL). While turmeric is the primary source of curcumin, pairing it with other anti-inflammatory foods like black pepper, healthy fats, and omega-3-rich foods can enhance curcumin’s absorption and effectiveness in Chainani-Wu N. Several studies have shown its potent antioxidant and anti-inflammatory effects, with non-toxicity and safety of use even at doses of 8 g per day []. Many clinical trials have been conducted to determine the effectiveness of curcumin in osteoarthritic patients. Ingesting curcumin by itself does not lead to the associated health benefits due to its poor bioavailability, Curcumin is a natural extract that possesses numerous physiological properties, as indicated by its anti-inflammatory action. In this pilot study, 24 CKD patients and 20 healthy volunteers were recruited. We found that curcumin attenuates the severity of EAE This study has demonstrated the feasibility of using the Fe-curcumin nanozyme as a nanodrug to inhibit inflammatory reactions and scavenge ROS in the treatment of in which natural antioxidants coordinate with Fe 3+ to form nanoparticles with excellent solubility for directing anti-inflammatory and ROS scavenging effects to treat EAU. Specifically, the biological, pharmaceutical and nutraceutical properties of curcumin are associated with its ability to downregulate the expression of the following genes: IκBα, cyclooxygenase 2, prostaglandin E2, interleukin (IL)-1, IL-6, IL-8 Background Curcumin, a natural polyphenolic substance, has been known for more than two millennia as having strong anti-inflammatory activity towards multiple ailments, including arthritis. Several studies have also suggested that this molecule has multiple pharmacological effects, such as anti-inflammatory, antioxidant, and antitumor effects. The main drawback of curcumin is its poor solubility in water, which leads to low intestinal absorption and minimal bioavailability. The clinical efficacy of curcumin in OA has been Curcumin is a secondary plant metabolite present in Curcuma longa L. Moreover, curcumin treatment has been shown to decrease macrophage infiltration in the kidneys of chronic renal failure rats and to block transactivation of NF-κB, indicating that the anti-inflammatory property of curcumin may be responsible for alleviating disease in this animal model . Curcumin also undergoes extensive first-pass metabolism through its glucuronidation and sulfation, with the production of metabolites that have shown to have Curcumin is known recently to have antioxidant, anti-inflammatory, anticancer effects and, thanks to these effects, to have an important role in prevention and treatment of various illnesses ranging notably from cancer to autoimmune, neurological, cardiovascular diseases, and diabetic. There is a growing body of literature that recognizes the anti-inflammatory effects of curcumin in the immune system. In recent years, it has become very popular in the biomedical field because of its wide range of pharmacological activities such as antioxidant, anti-inflammatory, anti-bacterial, anti-viral, anti-cancer and neuroprotective properties [8]. However, due to the instability of the molecule at physiological pH values and the poor solubility in water, Curcumin is known to have powerful anti-inflammatory and antiarthritic properties. Summary: Turmeric, particularly its active compound curcumin, is a potent anti-inflammatory agent that can help reduce the risk of chronic diseases like heart disease, cancer, and Alzheimer’s. The curcumin in turmeric has proven, strong anti-inflammatory properties that block the action of inflammatory molecules in the body. Brown explains that the active ingredient in turmeric is a natural compound (polyphenol) called curcumin, which has both antioxidant and anti-inflammatory properties. However, the exact mechanism by which curcumin shows its anti-inflammatory effects are not entirely understood. This natural molecule also exhibits antibacterial, antifungal, antiviral, antiprotozoal, and antiparasitic properties [12,13,14]. Curcumin (diferuloylmethane), a yellow pigment in the spice turmeric (also called curry powder), has been used for centuries as a treatment for inflammatory diseases. Curcumin has anti-inflammatory, anti-oxidative and immunomodulatory effects, and can inhibit T cell activation, proliferation and production of pro-inflammatory factors by acting on MAPKs, AP-1, NF-κB pathways. Safety and anti-inflammatory activity of curcumin: a component of turmeric (Curcuma longa). (2021). Antioxidant Benefits of Turmeric Background Curcumin, a natural polyphenolic substance, has been known for more than two millennia as having strong anti-inflammatory activity towards multiple ailments, including arthritis. Researchers are investigating whether it may help diseases in which inflammation plays a role — from arthritis to ulcerative colitis Furthermore, the HO-1 inhibitor abrogated curcumin anti-inflammatory effect in BV-2 microglial cells. Antioxidant Benefits of Turmeric Curcumin, a polyphenolic compound derived from Curcuma longa, has shown potential neuroprotective effects due to its anti-inflammatory and antioxidant properties. Data indicate that curcumin, a natural ingredient of the curry spice turmeric, acts as a NF-κB inhibitor and exhibits both anti-inflammatory and anti-cancer properties. (A) Graphical representation of curcumin treatment strategy. Curcumin is known to possess potent antioxidant and anti-inflammatory properties. A natural dyestuff found in the root of Curcuma longa. For subjects receiving daily doses of 4000 mg and 6000 mg, serum concentrations of curcumin were 0. Several experimental and pharmacologic trials have demonstrated its efficacy in the role as an anti-inflammatory agent. Studies on the toxicity and anti-inflammatory properties of curcumin have included in vitro, animal, and human studies. Evidence from multiple clinical trial studies suggests that curcumin can reduce the subjective experience of pain in patients with system-related disorders of muscle disease. In this study, we aimed to compare the anti-arthritic in Curcumin (CUR) is a natural hydrophobic polyphenol extracted from the rhizome of turmeric. The effect of turmeric or curcumin on a wide range of inflammatory markers has not been evaluated in a systematic review. Anti-inflammatory foods, exercise, adequate sleep, and stress management may help reverse chronic inflammation. Clinical trials suggest curcumin, in particular, has reduced joint pain, boosted cognitive function and mood, supported heart health, and more. Several studies have reported that a diet rich in antioxidants and anti-inflammatory compounds may decrease age-related cognitive decline and the risk of developing various diseases [1,2]. Consequently, curcumin is being considered as a potential treatment option for COVID-19 [10]. Studies show positive effects of curcumin on people suffering from conditions such as rheumatoid arthritis[1] and inflammatory bowel disease[2], amongst others[3]. Inflammation is now recognized as one of the main contributors to diabetes and may be ameliorated by diminishing the underlying causes . Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients. Conversely, curcumin can increase anti-inflammatory cytokine production, such as IL-10 [36] and soluble intercellular adhesion molecule 1 (sCAM-1) [37]. Curcumin (diferuloylmethane) is a bright yellow chemical derived from the turmeric (Curcuma longa L. Curcumin is characterized by extensive antioxidant activity. 63 ± 0. It has been reported that curcumin improved the effect of fibroblast-like synoviocytes in rheumatoid arthritis by modulating the inc00052/miR-126-5p/PIAS2 axis and inhibiting Janus Curcumin and Its Anti-Inflammatory Actions. ETO-curcumin exerts superior anti-inflammatory effects compared to standard curcumin on DSS-induced inflammation at 50 mg/kg body weight. In its own right, curcumin is known for its anti-inflammatory, anti-tumor and antioxidant effects (6, 7). Herein, we report Fe-curcumin-based nanoparticles (Fe-Cur NPs) with nanozyme functionalities in guiding the intracellular ROS scavenging and meanwhile exhibiting Curcumin is a bright colored polyphenolic moiety which is derived from the rhizomes of Curcuma longa of family Zingiberaceae. Inflammation has been identified as a symptom of other pathologies such as Alzheimer’s disease, Parkinson’s disease, Multiple sclerosis, epilepsy and Most of these benefits can be attributed to its antioxidant and anti-inflammatory effects. It has received a lot of attention because it contains curcumin, a powerful anti-inflammatory compound (52, 53, 54, 55). . Since curcumin is a well-established botanical with anti-inflammatory properties, we wanted to determine whether presence of Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease, and other chronic illnesses. The beneficial effect of curcumin on diabetes may be due to its ability to Turmeric extract or active component curcumin may have anti-inflammatory effects in people with chronic inflammatory diseases. Curcumin can maintain Graphical abstract. Here, we ident Curcumin has anti-inflammatory properties, making it a potential treatment for a number of health conditions, including pain, asthma and decreased movement in people with osteoarthritis. One disease that is very common and is associated with an ongoing We observed that turmeric/curcumin supplementation significantly reduces levels of inflammatory markers, including CRP (WMD: -0. Research has shown curcumin to be a highly pleiotropic molecule capable of interacting with numerous molecular targets involved in inflammation. , 2018), and the berberine combination also reduced inflammatory and oxidative The major constituent of turmeric, curcumin, is a bioactive phenolic compound that has been studied for its potential health benefits and therapeutic properties. Curcumin is a natural compound derived from the spice, turmeric, that has been extensively reported for its efficacy in controlling or treatment of several inflammatory diseases. Show more. A male patient who had diabetes for 16 years ingested 5 We developed an Fe-curcumin nanozyme in which natural antioxidants coordinate with Fe 3+ to form nanoparticles with excellent solubility for directing anti-inflammatory and ROS scavenging effects to treat EAU. According to Nutraceutica Bioavailability Classification Scheme (NuBACS), curcumin shows poor bioaccessibility, due to its low solubility in water and low stability []. To further support the role of curcumin in immunomodulation, studies have found that there is a correlation between anti-inflammatory effects of curcumin and down-regulation of microRNA-155 in Microenvironment-Responsive Antibacterial, Anti-Inflammatory, and Antioxidant Pickering Emulsion Stabilized by Curcumin-Loaded Tea Polyphenol Particles for Accelerating Infected Wound Healing ACS Appl Mater Interfaces. Subsequent research showed it to have anti-inflammatory properties, antioxidant properties, and several other marked benefits. 06 μm, respectively. Both clinical trials likely depend on the anti-inflammatory effects of curcumin. Curcumin, a yellow pigment from Curcuma longa, is a major component of turmeric and is commonly used as a spice and food-coloring agent. Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trials. The anti-inflammatory effects of curcumin have been shown in However, the mechanism by which curcumin mediates these anti-inflammatory effects in animals was not revealed until several years later, when our group showed that curcumin can suppress TNF-induced NF-κB activation (Singh and Aggarwal, 1995) and other groups showed that curcumin blocked TNF production in cell culture (Chan, 1995) and the expression of pro This study suggests that the cytokine-suppressive anti-inflammatory drug curcumin is able to downregulate chronic glial activation and protect against inflammation-induced neuronal damage, as we have This review is an attempt to summarize our current understanding of curcumin’s potential as a neuroprotectant and an antidepressant. Curcumin, through its chemical structure and the presence of hydroxyl and methoxy groups, is attributed to many properties, in particular antioxidant, antimicrobial, anti-inflammatory, anti-angiogenic, and antimutagenic ones [5,6,9,10,11,12]. Curcumin as an antioxidant, anti-inflammatory and lipophilic action improves the cognitive functions in patients with AD. rhizomes, shows potent antioxidant, anti-inflammatory, anti-cancer, and anti-atherosclerotic properties. Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease, and other chronic illnesses. 2024 Feb 28;16(8):9749-9767. Since curcumin is a well-established botanical with anti-inflammatory properties, we wanted to determine whether presence of essential turmeric oils have any additional bioactivity, and hence, we sought to test the differences in anti-inflammatory efficacy between ETO- and A conclusive summary of the pleiotropic action of curcumin in the body system: Curcumin exhibits anti-inflammatory, antioxidant, antiapoptotic, antitumor, and antimetastatic activities and suppresses multiple signalling pathways responsible for inflammation, apoptosis, and cellular death. It exhibits anti-inflammatory, antioxidant, and antitumor properties by modulating different intracellular mechanisms. Learn about the potential health benefits of herbs, such as turmeric and garlic. In the light of this information and according to the results of our study, it has been shown that curcumin is effective in the treatment of AP, and the effect of curcumin increases with the dose increase. Due to their low solubility in water, the curcumin molecules must be encapsulated into l Curcumin, derived from Curcuma longa (Turmeric), is not only known as a spice that gives a yellow color to food, but also a traditional medicine that has been widely used particularly for treating various malignant diseases, arthritis, allergies, Alzheimer's disease, and other inflammatory illnesses 1, 2. This review aims to synthesize current preclinical data on the anti-neuroinflammatory mechanisms of curcumin in the context of AD, addressing its pharmacokinetics, bioavailability Abstract. Curcumin has antioxidants and anti-inflammatory properties. On the other hand, the role of inflammatory signaling pathways has been Neuroinflammation is a pathophysiological process present in a number of neurodegenerative disorders, such as Alzheimer's disease, Huntington's disease, Parkinson's disease, stroke, traumatic brain injury including chronic traumatic encephalopathy and other age-related CNS disorders. Epub cells revealed that curcumin exerts aforementioned effects through its anti-inflammatory and atheroprotective properties (26). Other research suggests that curcumin may Hence, this review discusses the current knowledge on the anti-inflammatory, antioxidant, and immunomodulatory roles of curcumin with the hope of recruiting curcumin as a therapeutic agent in While some studies have shown promising results in terms of curcumin’s antioxidant, anti-inflammatory, and neuroprotective properties, there is still a need for more robust clinical trials and mechanistic studies to elucidate the specific pathways through which curcumin exerts its effects on aging-related processes. In preclinical studies, curcumin can reduce the degree of inflammation of animal skin [38] and prevent or reduce the respiratory tract inflammation caused by viral or bacterial infections [39] , [40] . Although it was found to induce apoptosis in cancer cells, the functional role of curcumin as well as its molecular mechanism in anti-inflammatory response, particularly in intestinal cells, has been less investigated. Curcumin, also known as diferuloylmethane, is an active component in the golden spice turmeric (Curcuma longa) and in Curcuma xanthorrhiza oil. In addition, over one hundred clinical studies have been carried out with curcumin. Curcumin is an antioxidant, which means it can efficiently Oxidative damage and inflammation have been pointed out in preclinical studies as the root cause of cancer and other chronic diseases such as diabetes, hypertension, Alzheimer's disease, etc. Thus, following a brief introduction of curcumin's Curcumin also have an important in the health management through its anti-inflammatory effects. Several studies have reported that curcumin has a high potential to be used as an anti Curcumin, the main active ingredient in turmeric, inhibits molecules known to play major roles in inflammation . Epidemiological and clinical studies have suggested that cancer could be prevented or significantly reduced by treatment with anti-oxidant and anti-inflammatory drugs, therefore, Curcumin, a yellow coloring agent extracted from turmeric, shows strong anti-oxidative and anti-inflammatory activities when used as a remedy for the prevention and treatment of chronic diseases. Several reports suggest that curcumin has the potential to prevent and treat MetS. Curcumin is a natural pigment isolated from turmeric. 74, -0. From these facts, the aim of Curcumin has the ability to suppress the acute and chronic inflammation. CKD patients followed nutritional counselling and were supplemented with curcumin (Meriva ®) Abstract. It is widely used due to its therapeutic effectiveness and acceptable safety specification [9,10]. A randomized, double-blind, controlled trial in a human model [ 74 ] evaluating the safety and efficacy of curcumin alone and in combination with diclofenac sodium in patients with active rheumatoid arthritis (RA) has shown that curcumin treatment is safe and is not associated with any adverse effects. Atherosclerosis is a comprehensive term for a series of degenerative and hyperplasic lesions such as thickening or sclerosis in large- and medium-sized arteries, causing decreased Curcumin is a natural herbal product that has been popularly used to treat autoimmune diseases in China; however, its effects on rheumatoid arthritis and its mechanism are not clear. 41), TNF-α Curcumin has been demonstrated to have therapeutic potential for various chronic inflammatory diseases, essentially due to its anti-inflammatory and anti-oxidative properties against a vast Curcumin is a natural extract that possesses numerous physiological properties, as indicated by its anti-inflammatory action. Epidemiological and clinical studies have suggested that cancer could be prevented or significantly reduced by treatment with anti-oxidant and anti-inflammatory drugs, therefore, Turmeric and its prominent bioactive compound, curcumin, have been the subject of many investigations with regard to their impact on inflammatory and oxidative balance in the body. Conclusion. However, due to the instability of the molecule at physiological pH values and the poor solubility in water, The spice turmeric, with its active polyphenol curcumin, has been used as anti-inflammatory remedy in traditional Asian medicine for centuries. Most of these benefits can be attributed to its antioxidant and anti-inflammatory effects. Using exosomes as a delivery vehicle, we provide evidence that curcumin delivered by exosomes is more stable and more highly concentrated in the blood. These included studies on the antioxidant, anti-inflammatory, antiviral, and antifungal properties of curcuminoids. This paper mainly reviews the anti-inflammatory effect of curcumin, the inflammatory pathological mechanism of related diseases, the regulatory effect of curcumin on these, and The anti-inflammatory effect of curcumin is most likely mediated through its ability to inhibit cyclooxygenase-2 (COX-2), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS). Curcumin is the primary active ingredient in the turmeric, and compelling evidence has shown that it has the ability to inhibit inflammation. Curcumin improves the growth of neurons and the Anti-inflammatory, antioxidant, antibacterial, and hypoglycemic qualities and the ability to promote wound healing and reduce sensitivity to chemotherapy and radiation have been revealed in curcumin. For this purpose, CNPs were prepared by dissolving curcumin into dichloromethane. Curcumin, a yellow polyphenol extracted from the turmeric root is used as a diet supplement. Among them, curcumin is a natural compound, and current studies have shown that curcumin has good anti-inflammatory, immunosuppressive and anticancer properties (28–30). Among natural compounds, curcumin, the main active component Sestrins are a class of stress-induced proteins that have antioxidation functions, regulating cell growth and metabolism. Curcumin is the main constituent of turmeric, the rhizome of Curcuma longa. It is a highly pleiotropic molecule that exhibits antibacterial, anti-inflammatory, hypoglycemic, antioxidant, wound-healing, and antimicrobial Curcumin has anti-inflammatory, anti-oxidative and immunomodulatory effects, and can inhibit T cell activation, proliferation and production of pro-inflammatory factors by acting on MAPKs, AP-1, NF-κB pathways. The mechanisms underlying these effects include the inhibition of One of the most promising properties of Curcumin is its ability as an anti-inflammatory agent. Curcumin as a potential candidate for the treatment of candidosis with anti-inflammatory activity was studied in a murine model Linpisarn S, Changsom D, Chawansuntati K, Wipasa J. This review aims to synthesize current preclinical data on the anti-neuroinflammatory mechanisms of curcumin in the context of AD, addressing its pharmacokinetics, bioavailability, and potential as a therapeutic Turmeric (Curcuma longa), a commonly used spice throughout the world, has been shown to exhibit antiinflammatory, antimicrobial, antioxidant, and anti-neoplastic properties. Although there Curcumin was able to suppress the expression of MMP-3 and MMP-9, COX-2 (enzyme responsible for synthesis of prostaglandin E-2 [PGE-2]), and PGE-2 (mediator of inflammation) in human primary chondrocytes induced by IL-1β or TNFα. Curcumin has potent anti-oxidant and anti-inflammatory properties and can reduce the accumulation of AGEs. “Curcumin has many biological activities, not all of which are Suppression of NF-κB activation is a topic actively being pursued in the academic and industrial settings. 4. Curcumin is well known for possessing anti-inflammatory properties and for its beneficial effects in the treatment of asthma. 4c08717. In this study, we aimed to compare the anti-arthritic in Curcumin, the primary yellow biocomponent of turmeric, has anti-inflammatory, antioxidant, anticarcinogenic, antidiabetic, antibacterial, antiprotozoal, antiviral, antifibrotic, immunomodulatory, and antifungal properties. Curcumin, a yellow coloring agent extracted from turmeric, shows strong anti-oxidative and anti-inflammatory activities when used as a remedy for the prevention and treatment of chronic diseases. Its anti-fibrotic effects in glomerular disease is suggested in its action of blocking fibrosis in anti-Thy1 glomerulonephritis through up-regulation of hemoxygenase-1 gene expression. Current study investigates the immunomodulatory and anti-inflammatory effects of curcumin using mouse model of ovalbumin-induced allergic asthma. A randomised, pilot study to assess the efficacy Curcumin affects tumor growth by disrupting the activity of several enzymes that allow for growth and proliferation. Bioavailability of Curcumin. Curcumin is a well-documented herbal anti-inflammatory agents. Summary. 58,59,67,68 Comblain et al demonstrated that curcuminoids decreased the gene expressions of MMP-3, ADAMTS4, ADAMTS5, COX-2, Curcumin is a beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. This review considers the current evidence for curcumin to impact muscle recovery following exercise to improve performance and the potential mechanisms of action. Curcumin has shown considerable anticancer effects against several different types of cancer, including prostate cancer, breast cancer, colorectal cancer, pancreatic cancer, and head and Turmeric, a dried powder derived from the rhizome of Curcuma longa, has been used for centuries in certain parts of the world and has been linked to numerous biological activities including antioxidant, anti-inflammatory, anticancer, antigrowth, anti-arthritic, anti-atherosclerotic, antidepressant, Curcumin derived from Curcuma species is an anti-inflammatory compound as such. In patients with rheumatoid arthritis, curcumin is able to up regulate pro-apoptotic Bax, and down regulate anti-apoptotic B-cell lymphoma 2 (Bcl-2) and X-linked inhibitor of apoptosis protein (XIAP), inducing apoptosis and, therefore, inhibit the growth of Overall, curcumin exerted anti-inflammatory effects in adipocytes, in part by reducing IL-6, and these effects may be linked to the upregulation of the mTOR signaling pathway, warranting additional mechanistic studies on the effects of curcumin and its metabolites on metabolic health. Nuclear factor kappa B (NF-κB) is a key signaling molecule in the elaboration of the inflammatory response. Abstract. The mechanism of action by which Chemical structure of curcumin. Curcumin, the dietary polyphenol isolated from Curcuma longa (turmeric), is commonly used as an herb and spice worldwide. This technology provides a means for anti-inflammatory drugs, such as curcumin, to target the inflammatory cells as well as to overcome unwanted off-target effects that limit their utility. Curcumin, the active ingredient of the Curcuma longa extract, has been studied widely over the past few decades for its anti-inflammatory, antioxidant, anticancer, and antiandrogenic effects. Curcumin, due to its anti-inflammatory properties, can inhibit NF-κB activity and decrease the level of TNFα, which is the most effective activator of the NF-κB pathway [81,107]. Background Curcumin is a natural anti-inflammatory agent that has been used for treating medical conditions for many years. Several clinical trials have demonstrated curcumin’s antioxidant, anti-inflammatory, and antineoplastic effects. 1021/acsami. Curcumin (Cur), a Chinese herbal, has Nevertheless, curcumin is the most researched active ingredient for its numerous pharmacological effects. International Immunopharmacology. Author links open overlay panel Mohammad Jafar Dehzad a, Hamid Ghalandari b, Mehran Nouri b, Moein Askarpour a. We performed a systematic review of randomized cont Among those, curcumin has demonstrated significant in vitro anti-inflammatory properties. We performed a systematic review of randomized cont Chronic inflammation is a key driver of cancer development. In this systematic review and meta-analysis, we summarized the existing literature on randomized controlled trials (RCT This review mainly focuses on the anti-inflammatory potential of curcumin and recent developments in dosage form and nanoparticulate delivery systems with the possibilities of therapeutic application of curcumin for the prevention and/or treatment of cancer. Curcumin contains polyphenols, which are substances that act at the cellular level on inflammation and oxidation, alleviating the effects of pathologies such as arthritis, anxiety, high blood fat levels and metabolic syndrome. Turmeric is used to treat many health problems, such as skin and digestive issues. Studies over the past decade have indicated that curcumin-free turmeric (CFT) components possess numerous biological activities including anti-inflammatory, anticancer, and antidiabetic activities. Pneumonia, such as acute lung injury (ALI), has been a type of lethal disease that is generally caused by uncontrolled inflammatory response and excessive generation of reactive oxygen species (ROS). Try adding turmeric to curries, soups, or smoothies. We r In the current study, the anti-inflammatory effects of curcumin were evaluated relative to various chronic inflammatory diseases. Growing evidence shows that an active component of turmeric, curcumin, may be used medically to treat a variety of dermatologi Curcumin has long been used in both Ayurvedic and Chinese medicines as an anti-inflammatory agent, a treatment for digestive disorders, and to enhance wound healing. Ingesting curcumin by itself does not lead to the associated health benefits due to its poor bioavailability, which appears to be primarily due to poor In UC patients with mild-to-moderate disease, 3 g curcumin, in combination with the anti-inflammatory drug, mesalamine, induced remission in over 50% of the study population . ) rhizome and has been reported to be a potent anti-inflammatory agent . Anti Furthermore, curcumin exhibits anti-inflammatory, anticoagulant, antiplatelet, and cytoprotective effects, that may help prevent the progression of inflammatory diseases [14]. Curcumin is a compound found in the spice turmeric, Curcumin has anti-inflammatory, anti-oxidative and immunomodulatory effects, and can inhibit T cell activation, proliferation and production of pro-inflammatory factors by acting on MAPKs, AP-1, NF-κB pathways. Turmeric is a powerful antioxidant Curcumin supplementation enhances the anti-inflammatory capacity of the eicosanoid pathway in rheumatoid arthritis patients by modulating serum lipid levels to a normal state . Curcumin, a natural polyphenolic compound present in Curcuma longa L. The desirable preventive or putative therapeutic properties of curcumin have also been considered to be associated with its antioxidant and anti-inflammatory properties. 5. Curcumin is widely used as natural medicine because it has various physiological activities such as an anti-inflammatory [4], antioxidant, and anticancer drug [5]. Within this article, the anti-inflammatory, antioxidant and antithrombotic properties and mechanisms of action of curcumin are thoroughly reviewed and the main focus is shifted to its associated health Curcumin, a polyphenolic compound derived from Curcuma longa, has shown potential neuroprotective effects due to its anti-inflammatory and antioxidant properties. Curcumin is a polyphenol with potent anti-inflammatory properties [12]. Turmeric is traditionally used as a spice and coloring in foods. Curcumin’s ability to decrease blood sugar levels in human patients was first reported in 1972 . The commercially available drugs lower serum uric acid levels and reduce inflammation, but these standard therapies have many side effects. 2024 Aug 28;16(34):44467-44484. Nitrite levels, which are regulated by inducible nitric oxide synthase (iNOS), play a critical role in inflammation. Curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric (Curcuma longa) that has been associated with antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial activities as indicated by over 6,000 citations. Curcumin is a polyphenolic substance naturally occurring in turmeric, especially in Curcuma Longa, with broad anti-inflammatory properties and proven positive effects in autoimmunological disease therapies, including RA. A number of anti-inflammatory drugs such as nonsteroidal anti-inflammatory agents have been proposed to alleviate chronic inflammatory reactions after radiotherapy or chemotherapy. Extensive research within the past two decades has shown that curcumin mediates its The treatment of diabetic chronic wounds is still faced with great challenges, mainly due to wound infection, excessive inflammation, and peripheral vascular disease in the wound area. 1. Based on the available pharmacological data obtained from in vitro and in vivo research, as well as clinical trials, an opportunity exists to translate curcumin into clinics for the prevention of inflammatory diseases in the near future. But, it is believe that curcumin shows role as anti-inflammatory via inhibition of enzymes such as cyclooxygenase-2 (COX-2) and 5 The anti-inflammatory activity of curcumin has also been described in numerous systemic inflammatory pathologies and tumors. J Altern Complement Med 2003;9 (1): 161-8 2. Health Benefits Claims about the health benefits of curcumin abound. Anti-inflammatory effects of curcumin Curcumin (CUR) is a polyphenol extracted from the rhizome of Curcuma longa that possesses potent anti-inflammatory and antioxidant potential. Despite CUR’s numerous beneficial effects on human health, it has limitations, such as poor absorption. We and others subsequently showed that curcumin blocks NF-κB activation through Turmeric and curcumin have anti-inflammatory and antioxidant properties. This review aims to summarize the antiosteoarthritic effects of curcumin derived from clinical and preclinical studies. It has a role as a metabolite, an anti-inflammatory agent, an The spice turmeric, with its active polyphenol curcumin, has been used as anti-inflammatory remedy in traditional Asian medicine for centuries. However, the mechanism mediating its anti-inflammatory effects are not fully understood. 11 μm and 0. Curcumin, a polyphenolic compound derived from Curcuma longa, has shown potential neuroprotective effects due to its anti-inflammatory and antioxidant properties. Several experiments were used to Curcumin, the main active ingredient in turmeric, inhibits molecules known to play major roles in inflammation . Microglia-mediated neuroinflammation plays an important role in multiple sclerosis (MS). Defense assessment tests showed that curcumin is tolerated well at high doses, without adverse effects. While the anti-oxidant and anti-inflammatory effects of curcumin, a natural Because of its anti-inflammatory property, curcumin represents a promising therapeutic option for T2DM. Curcumin possesses several biological activities such as anti-inflammatory [11,12], anticancer , antioxidant and the ability to heal wounds . This study explored whether curcumin has a protective effect on experimental autoimmune encephalomyelitis (EAE), and the specific mechanism was investigated. Curcumin, a major component of the Curcuma species, contains antioxidant and anti-inflammatory properties. It is also used as a cosmetic and in some medical preparations. Because of its bio-pharmacological effects curcumin is also called “spice of life”, in fact it is recognized that curcumin possesses important proprieties such as anti-oxidant, anti-inflammatory, anti-microbial, antiproliferative, anti-tumoral, and anti-aging. Chandran B, Goel A. A phase 1 human trial with 25 subjects using up to 8000 mg of curcumin As curcumin has also been shown to possess anti-inflammatory, antioxidant and anticarcinogenic activities, it was of interest to investigate whether the marked effect of this yellow pigment on HO-1 expression and heme oxygenase activity observed at physiological oxygen levels could also be reproduced in hypoxic conditions. Numerous in vitro and in vivo studies have confirmed the health-promoting effects of curcumin associated primarily with its strong antioxidant and anti-inflammatory activities [9,10,11]. 3c16837. We have shown that short-term cell treatment with low concentrations of curcumin has a positive effect on normal young cells by decreasing the level of secreted pro Curcumin is a polyphenolic compound contained in turmeric (Curcuma longa, Family: Zingiberaceae). The mechanisms underlying these effects include the Curcumin's effect on cancer (from an anti-inflammatory perspective) will also be discussed; however, an exhaustive review of its many anticancer mechanisms is outside the scope of this article. We investigated the impact of these curcuminoids found in Ryudai gold, an approved cu Anti-Inflammatory, Wound Healing, and Anti-Diabetic Effects of Pure Active Compounds Present in the Ryudai Gold Variety of Curcuma longa. Therefore, it is of great importance to develop a novel multifunctional hydrogel with high efficiency to accelerate diabetic wound healing. Here, we ident Abstract. It has been used for centuries for its antioxidant, anti-inflammatory and antibacterial Conversely, curcumin can increase anti-inflammatory cytokine production, such as IL-10 [36] and soluble intercellular adhesion molecule 1 (sCAM-1) [37]. Keywords: curcumin, cancer, anti-oxidant, anti-inflammatory, nanoparticles. Curcumin, the powerful anti-inflammatory compound found in turmeric, offers numerous health benefits, especially for those dealing with chronic inflammation. This dual property confers a unique advantage to this herbal medication, believed to be Results: A large number of studies on curcumin were identified. Additionally, in vitro studies of curcumin showed anti-inflammatory action on human vascular cells. 58 mg/l, 95 % CI: -0. The antioxidant and anti-inflammatory effects of curcumin are known. Curcumin exerts anti-inflammatory effects in DSS-induced colitis. Antioxidant Effects. Curcumin has potent anti-inflammatory properties, including the ability to downregulate certain inflammatory signaling molecules such as TNF, NK-κβ, and COX-2. 51 ± 0. To date, clinical studies have considered the potential role of curcumin to Certain herbs and spices may have anti-inflammatory properties. Our laboratory was the first to demonstrate that curcumin is a potent blocker of NF-κB activation induced by different inflammatory stimuli (Singh and Aggarwal, 1995). Since curcumin is widely used as a food colorant in thermally processed food it may undergo substantial chemical changes which in turn could affect its biological activity. BALB/c mice were immunized w Curcumin (diferuloylmethane) is a bright yellow chemical derived from the turmeric (Curcuma longa L. Curcumin, the major component of the Curcuma longa rhizome, has various pharmacological actions, including anti-inflammatory, immune-regulatory, anti A Multifunctional, Tough, Stretchable, and Transparent Curcumin Hydrogel with Potent Antimicrobial, Antioxidative, Anti-inflammatory, and Angiogenesis Capabilities for Diabetic Wound Healing ACS Appl Mater Interfaces. It reduces inflammation by lowering histamine levels and by possibly increasing the production of natural cortisone by adrenal glands . Chronic inflammation may also lead to the development of second cancer during years after treatment. This review aims to synthesize current preclinical data on the anti-neuroinflammatory mechanisms of curcumin in the context of AD, addressing its pharmacokinetics, bioavailability, and potential as a therapeutic Most of these benefits can be attributed to its antioxidant and anti-inflammatory effects. 10 A study of 12 subjects given either 10 g (n = 6) or 12 g (n = 6) curcumin orally suggests that curcumin has better oral absorption at higher doses than at lower doses and that the levels in plasma are detected as Nutrients and their potential benefits are a new field of study in modern medicine due to their positive impact on health. ltf qsam eicoo rzxqzl xrjhjp jlvi zamyngt robiitwu ikwu awsgu
